Pure Encapsulations MethylAssist offers a naturally occurring and more bioavailable form of folate. MethylAssist supports essential methylation reactions to promote cardiovascular, neural and emotional health with Metafolin® L-5-methyltetrahydrofolate (L-5-MTHF) and activated B vitamins. Metafolin® is the naturally occurring, universally metabolized form of folate and activated B vitamins work to support healthy methylation, cardiovascular, neural and emotional health.