Clinically proven to benefit brain and joint function, SAMe (S-Adenosylmethionine) is an amino acid derivative that has undergone dozens of trials involving thousands of patients. Also called activated methionine (an essential amino acid) since it is formed by the combining of ATP with methionine, SAMe is found in all living cells. Manufactured under low temperature and low humidity, SAMe 200 is coated with enteroguard® to ensure a biologically active product. It is made naturally by microbiological fermentation and then specially processed to preserve 68-80% (S,S) SAMe, the highest active level available.